产品货号：
Z12120
中文名称：
AXL抗体
英文名称：
Anti-AXL Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AXL Antibody (C-term) |
| 指标别名 | AXL;AXL oncogene;AXL receptor tyrosine kinase;JTK11;UFO |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB |
| 基因名称 | AXL |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This AXL antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 838-872 amino acids from the C-terminal region of human AXL. |
| 计算分子量 | 98kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival,cell proliferation,migration and differentiation.Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL.Following activation by ligand,ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1,PIK3R2 and PIK3R3;but also GRB2,PLCG1,LCK and PTPN11.Other downstream substrate candidates for AXL are CBL,NCK2,SOCS1 and TENC1.Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis,optimal cytokine signaling during human natural killer cell development,hepatic regeneration,gonadotropin-releasing hormone neuron survival and migration,platelet activation,or regulation of thrombotic responses.Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.In case of filovirus infection,seems to function as a cell entry factor. |
| Uniprot ID | P30530 |
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